Intrinsic Factor Blocking Antibody

Intrinsic Factor Blocking Antibody

Preferred Specimen(s) 1 mL serum

Transport Container Plastic screw-cap vial

Transport Temperature Refrigerated (cold packs)

Reject Criteria Grossly hemolysed

Methodology Immunoassay

Clinical Significance Intrinsic Factor, produced by cells lining the stomach, binds vitamin B12 (cyanocobalamin) to facilitate absorption of the vitamin. Blocking antibody impedes the action of Intrinsic Factor as observed in approximately half of the patients who develop pernicious anemia.

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