Epstein – Barr virus Nuclear Antigen (EBNA) Antibody (IgG)

Epstein – Barr virus Nuclear Antigen (EBNA) Antibody (IgG)

Preferred Specimen(s): 1 mL serum

Minimum Volume: 0.2 mL

Transport Temperature: Room temperature

Specimen Stability:

• Room temperature 4 days
• Refrigerated 7 days
• Frozen 30 days

Reject Criteria: Gross hemolysis

·         Gross lipemia

·         Icteric

Methodology: Immunoassay (IA)

Reference Range(s)

Value	Interpretation
≤0.90	Negative
0.91-1.09	Equivocal
≥1.10	Positive

Clinical Significance: Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgG is typically detectable at clinical presentation, and persists for life. Absence of VCA-IgG usually indicates the patient is susceptible to EBV infection.

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