Epstein-Barr Virus Antibody Panel

Epstein-Barr Virus Antibody Panel

Includes: Epstein – Barr virus VCA Antibody (IgM), Epstein-Barr Virus VCA Antibody (IgG), Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Preferred Specimen(s): 1 mL serum

Minimum Volume: 0.6 mL

Transport Container: Plastic screw-cap vial

Transport Temperature: Room temperature

Specimen Stability:

• Room temperature 4 days
• Refrigerated 7 days
• Frozen 30 days

Reject Criteria:

·         Gross hemolysis

·         Gross lipemia

·         Icteric

Methodology: Immunoassay (IA)

Reference Range(s)

Epstein – Barr virus VCA Antibody (IgM)

≤0.90	Negative
0.91-1.09	Equivocal
≥1.10	Positive

Epstein – Barr virus VCA Antibody (IgG)

≤0.90	Negative
0.91-1.09	Equivocal
≥1.10	Positive

Epstein – Barr virus Nuclear Antigen (EBNA) Antibody (IgG)

≤0.90	Negative
0.91-1.09	Equivocal
≥1.10	Positive

Clinical Significance: Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, and then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA-IgG are typically detectable at clinical presentation, and persist for life. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life.

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