CALCITONIN, Serum

CALCITONIN, Serum

Patient Preparation: Overnight fasting is preferred.

Preferred Specimen(s): 1 mL serum

Minimum Volume: 0.5 mL

Specimen Container: Plastic screw-cap vial

Transport Temperature: Frozen

Specimen Stability

• Room temperature: unacceptable;
• refrigerated 24 hours;
• Frozen 28 days

Methodology: Immunoassay

Limitations: Basal concentrations of >100 pg/mL have been found to have 100% positive predictive value for medullary thyroid cancer.  Lower concentrations may be observed in some patients with clinically apparent medullary thyroid cancer.

Clinical Significance: Calcitonin concentration is increased in patients with medullary thyroid carcinoma. Calcitonin concentrations may be used to monitor disease.

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