Cyclic Citrullinated Peptide (CCP) Antibody IgG

Preferred Specimen(s) 1 mL serum

Transport Container Plastic screw-cap vial

Transport Temperature

Room temperature 8 hrs,
Refrigerated 48 hrs,
-20oC Long term

Reject Criteria

Gross hemolysis
Gross lipemia
Plasma

Methodology ELISA

Clinical Significance: A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about

2% of random blood donors and disease controls subjects are positive.