Phospholipid Antibody IgM

Phospholipid Antibody IgM

Preferred Specimen(s) 1.0 mL serum

Transport Container Plastic screw-cap vial

Transport Temperature

• Refrigerated 3 days,
• -20oC Long term

Reject Criteria

• Gross hemolysis
• Plasma

Methodology ELISA

Clinical Significance Phospholipid autoantibodies specific to phosphatidylinositol(PI), phosphatidylglycerol(PG),phosphatidylserine(PS),phosphatidylethanolamine(PE),phosphatidylcholine(PC),phosphatidic acid(PA), cardiolipin(CL) and sphingomyelin are found in hematolgic autoimmunediseases, especially antiphospholipid syndrome(APS) and systemic lupus erythematosus(SLE). APS is characterized by arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss; thrombosis, thrombocytopenia and hemolytic anemia also occur in SLE and are associated with the presence of phospholipid autoantibodies. Women with infertility showing spontaneous abortion or in vitro fertilization failure demonstrate PI autoantibodies in 25% of cases.

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