Sex Hormone Binding Globulin (SHBG)

Preferred Specimen(s) 1 mL serum

Transport Container Plastic screw-cap vial

Transport Temperature

Ambient 5 days,
Refrigerated 7 days

Reject Criteria

Gross hemolysis
Plasma

Methodology Chemiluminescene

Clinical Significance Testosterone, dihydrotestosterone and estrogens circulate in serum bound to Sex Hormone Binding Globulin (SHBG). SHBG concentrations are increased in pregnancy, hyperthyroidism, cirrhosis, oral estrogen administration and by certain drugs. Concentrations are decreased by testosterone, hypothyroidism, Cushings syndrome, acromegaly and obesity.